THE DEA 1 ANTIGEN (New data)

 

Alvedia’s scientific team established that DEA 1 antigen presents a large range of expression level on the RBC surface by using flow cytometer technology. Similarly to the Rhesus D molecule in human (named weak D or Du), some dogs express low level of DEA1 antigen (called weak DEA 1). This work  shows that the weak DEA 1 were previously typed as DEA 1.2 positive dogs. A large study on more than 750 dogs shows that our membrane technology detects perfectly all range of DEA 1 antigen expression from strong to very weak. Consequently, the DEA 1 line will always show different intensities.

 

 

 

Alvedia's technology reliable in case of auto-agglutination 

 

Thanks to our specific membrane technology, the agglutinated red blood cells will be retained at the bottom of the membrane whereas non agglutinated rbc will carry on migrating until the top of the membrane.

In some rare cases, it can happen that the auto-agglutination is too strong to obtain a reliable result (migration).

For example: It can occur in case of cold agglutinin. (See Troubleshooting Procedure)

 

 

Alvedia's technology reliable in case of low pcv (anemia) 

 

Thanks to the sensitivity of our specific monoclonal antibodies, even a low pcv will allow you to obtain a reliable blood typing.

CROSSMATCH SCIENTIFIC DATA

DIRECT ANTIGLOBULIN TEST CLINICAL INFORMATION

 

A postive DAT is the corner stone to establish the IMHA diagnosis. In a dog suffering from anemia it is mandatory to perform a DAT as illustrated by the following cases.

 

CLINICAL CASE N°1

 

Name of patient: Vanda

Symptoms: Weakness, Lethargy, Pale Mucous membranes, Anorexia.

Biology: Anemia (PCV: 6,5%, Hb: 4,4g/L)

 

DAT: POSITIVE

 

 

 

 

Cause: IMHA

 

 

CLINICAL CASE N°2

 

Name of patient: Benji

Symptoms: Weakness, Lethargy, Small haematomas, Haematuria.

Biology: Anemia (PCV: 13,7%, Hb: 4,5g/L)

 

DAT: NEGATIVE

 

 

 

 

Cause: Haemostasis disorder

 

 

 

TROUBLESHOOTING PROCEDURE

 

For Quick Test & Lab Test bt

 

If you have any problem with our products, do not hesitate to contact us.

Click on the picture to download

THE TROUBLESHOOTING PROCEDURE

ALVEDIA'S DATASHEETS

 

- Feline blood transfusion datasheets

 

- Canine blood transfusion datasheets

 

BLOOD COMPATIBILITY

 

Before any transfusion, always verify blood compatibility between donor and recipient.

Click on the pictures to download THE DATASHEETS

© 2013 Copyright Alvedia